Thursday, May 31, 2012

Can Ketamine Alleviate Bipolar Depression and Suicidal Thoughts?



A recent study undertaken by researchers at the National Institute of Mental Health found a single dose of ketamine was able to drastically reduce suicidal thoughts in patients with bipolar depression. Bipolar disorder occurs when a patient suffers sever mood swings that may range from mania to depression; patients who have this disorder are often at risk for suicide.

In the study led by Dr. Carlos Zarate, patients were either given a placebo or the ketamine treatment on two different days for two different weeks. The study found that the “in the ketamine group, depression symptoms significantly improved within 40 minutes, and remained improved over 3 days. Overall, 79 percent of the patients improved with ketamine, but none reported improvement when they received placebo”. The findings are a breakthrough in medicine because, traditionally, patients suffering from bipolar disorder are often treated with antidepressants which may take longer or need higher dosages to work and may not even be effective since patients could still suffer episodes while on medication, but the ketamine was able to rapidly reduce suicidal thoughts in just under an hour. This is very vital for future research into medication because patients with bipolar depression are often at high risk for suicide. Dr. Zarate said “We think that these findings are of true importance given that we only have a few treatments approved for acute bipolar depression, and none of them have this rapid onset of action; they usually take weeks or longer to have comparable antidepressant effects as ketamine does.”

Ketamine is often used in tandem with sedatives as a potent anesthetic. It acts a receptor antagonist, meaning it blocks the actions of N-methyl-D-aspartate (NMDA). Zarate said of the ketamine’s effectiveness, “…Confirmation that blocking the NMDA receptor complex is involved in generating rapid antidepressant and antisuicidal effects offers an avenue for developing the next generation of treatments for depression that are radically different than existing ones”.

Source:

Written By: Salma Khan

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Tuesday, May 29, 2012

Do We Expect too Much From Marriage?


Most young girls dream of becoming a bride. Fairytales like Cinderella set the precedent for marriage. We all want to find the perfect partner who will meet all of our needs and live happily ever after together. Just about everyone believes the myth of the perfect marriage since between seventy and ninety percent of the population will be married; yet, over half of all marriages in the U.S will end in divorce. So, what are we doing wrong? Why can’t we make the happily ever after fantasy a reality? Arizona State University sociologist Mary Laner thinks that it’s because we expect too much from our marriage. We expect marriage to solve all of our problems and meet all of our needs. We want to find a partner who will do it all: take care of the children, cook amazing meals, pursue a professional career while letting us pursue ours, and be a friend, confidante, and lover. This leaves one person with an impossible volume of needs to fulfill. When we realize that our partner cannot possibly live up to our ideals of the perfect mate, we become angry at the other person and may leave the marriage. These expectations could be a result of feeling alone in our individualistic society. Since we feel depersonalized in many superficial interactions with others in many places, we long for very close and intimate primary relationships. It’s common to expect a lot out of these relationships because we see them as few and far between; yet, in doing so we set ourselves up for the disappointment of finding out that one person can’t fulfill all of our needs or be the perfect person that we expect them to be. The key to a happy and long lasting marriage may be accepting that marriage is never going to be everything that we think it will be like in fairytales.
Written by Lisa Drake
http://psychcentral.com/lib/2012/the-myth-of-the-perfect-marriage/

Lowering the Risk of Suicide in Depressed Children and Adolescents




In an article in Current Psychiatry, ”How to lower suicide risk in depressed children and adolescents”, researchers Shailesh Jain (MD, MPH, ABDA), Rakesh Jain (MD, MPH), and Jamal Islam (MD, MS) discuss how to determine whether a child is at risk as well as treatment options depending on the severity of their symptoms.  Depression often goes undiagnosed in children and adolescents and is just as often undertreated. It is a challenge to detect it and treat it in young children, especially with due consideration that depression may occur as a result of genetic predisposition or dysfunctional parenting.

The average duration of depression in children and adolescents is about seven to eight months. Symptoms often vary with age. In children of pre-school age, depressive symptoms may manifest as somatic and behavioral problems. Children are often sad or irritable. Older children exhibit sadness and lose interest in social activities. Adolescents feel an array of symptoms such as feeling mentally and physically fatigued, loneliness, anger, uncertainty, and many others. Patients with subsyndromal depressive symptoms—where relapse and recurrence are common, may suffer depressive episodes even into adulthood. Factors to watch out for in these cases include “severity of depressive episodes, concurrent psychotic symptoms, suicidal thoughts, history of recurrent depressive episodes, threshold of residual symptoms, recent stressful life vents, adverse family environ, and family history of depression”.

The best way to determine the appropriate method of treatment for children is through proper assessment techniques. Informal interviews like the Child and Adolescent Psychiatric Assessment, the Kiddie Schedule for Affective Disorder and Schizophrenia, and the Diagnostic Interview for Children and Adolescents are often helpful in understanding and assessing the problem. Therapists often assess children to see if they have any “emotional difficulties, lack of developmental progress, levels of distress, impairment in functioning”, and whether or not they are danger to themselves or others around them.

Treatment options vary depending on the severity of the patient’s symptoms. Patients who have mild cases of depression often use psychotherapy, usually in the form of cognitive-behavioral therapy (CBT) to treat their problems. However, patients with more moderate to severe forms of depression will use antidepressants or a combination of both antidepressants and psychotherapy, a treatment often used for older adolescents who have treatment-resistant depression. Common antidepressants include brands like Citalopram, Celexa, Fluoxetine, Prozac, Sertraline, Zoloft, Venlafaxine, and Effexor. In much more serious cases where high risks of suicide are involved, hospitalization may be required for the patient.

There are four recommendations for lowering the risk of suicide in vulnerable children, as explained by the researchers. The first is to create a “safety plan” which entails directing the patient’s behavior in a certain situation. For example if a patient is feeling depressed or has suicidal thoughts, they should do something or contact someone to address the problem. Another recommendation is creating a “hope box” where a patient collects mementos and other things that give them reasons to want to live and give them hope. This should be accessible at all times so the patient can use it any time they feel they are in a state of despair or facing a mental crisis. A third suggestion is counteracting alienation. Patients may feel isolated or as if they are bothering others, so they should be encouraged to participate in more social activities, no matter how small they may be. For many children, the feeling of being alone may drive their suicidal behavior. Lastly, management of “overarousal” is another effective strategy. Overarousal is often manifested as an agitation of some kind. By addressing and reducing the agitation, patients would be less driven to a state where they feel depressed. On such example of agitation is insomnia, and effective ways of treating it include better sleep hygiene, stimulus control techniques, and sleep restriction.  

In addition to the four recommendations provided by researchers, a good support system of peers and family, high self-esteem and self-confidence from acceptance through social interactions and “body image satisfaction”, and a sense of “religious and existential well-being" where patients feel they have meaning and some kind of purpose in life are often attributed to children who have low rates of depression. 

Source:
Jain, S., Jain, R., Islam, J. (2012). How to lower suicide risk in depressed children and adolescents. Current Psychiatry, 11(5), 21-31

Written By: Salma Khan

Memorial Day Weekend: The Time of Year To Celebrate Those Who Have Fought For Our Country



Memorial Day weekend is usually the summer kick-off to every year. Thousands of people take their annual beach trips and enjoy the sun, beach, barbeques, and more. However, what most of these people often forget about are those whom we are celebrating: the Veterans.

According to a May 28, 2012 Newsweek magazine article, author and former marine, Anthony Swofford, discusses the increasing number of veterans who commit suicide each year and he even reports that “[a]bout 18 veterans kill themselves each day.” The article emphasizes on the stresses and hardships that the veterans experience when they return from war, such as multiple deployments and the amount of time lagging between deployments, which ultimately may contribute to their suicidal feelings. Another common hardship faced by the veterans is Post Traumatic Stress Disorder which, according to the American Psychological Association, is an anxiety disorder in which individuals who have had traumatic experiences may relive these experiences, have flashbacks, and/or have nightmares and their anxious feelings often interfere with their everyday lives. Swofford discusses different types of therapy that have been used on veterans. One type of therapy in particular is prolonged exposure therapy, or treatment in which a patient tape records the most traumatic event they experienced and listens to the recording every day for a week. The therapy is then repeated for three months. According to the article, this has been an effective way for the veterans to face their fears, but can also be quite difficult for the patients to do repeatedly.

In addition, the article discusses the loneliness and isolation that veterans may experience post-combat. Swofford, himself, served as a Marine for four years during the Gulf War and experienced little social interaction post-war, such as working in jobs that involved little human interaction. Lack of social interaction can be harmful to anyone and engaging in social activities is extremely important. One example that he points out is XSports4Vets, which is a group that allows veterans to engage in sports activities with other fellow veterans. Activities such as these can help our veterans feel a sense of community and make them feel more welcomed.

Memorial Day weekend is the perfect time of year to celebrate and give back to those who have fought for our country. Enjoy the beach and barbeques, but do not forget about those who have defended our country. If you know any veterans or any family members of veterans, make an effort to spend time with them and show your appreciation.






The End of the Phone Call: Can Texting Hinder our Relationsips?

Cell phones are being used now more than ever not to make phone calls, but as tools for written communication. Texting allows us to stay connected with friends and family instantly. Now, more people are hesitating to make an old fashioned phone call. According to market researcher Neilson, the amount of phone calls has decreased twelve percent since 2009. Increasingly, people seem to feel more and more uncomfortable with phone calls. Salon.com quotes a person’s reaction to even a voicemail as, “I cannot handle how uncomfortable it makes me. There is an intimacy that seems too great, like a song that was written just for me.” This new era of written communication does create a distance between people. Those wanting to avoid a confrontation with friends can hide behind a screen instead of speaking with them face to face. In this way, texting can increase avoidant tendencies by creating an easy way out for people to avoid unpleasant or awkward situations. If we confront these situations in person, we may be better able to grow and learn how to communicate with others. Texting seems impersonal since ideas are expressed solely through written messages without dealing with tone of voice, body language, and facial expressions. Though, without these clues, we lose an integral point of connection with another person. Texting can’t substitute a meaningful connection with someone else that is better formed in person. It may be a good tool to keep up with others sometimes, but if we rely too heavily on technology to communicate, we may unintentionally distance ourselves from each other. Though, it doesn't have to hinder our relationships if we remember to spend time in person with those who are important in our lives.

http://blogs.psychcentral.com/gentle-self/2012/05/the-end-of-the-phone-call/
http://psychcentral.com/blog/archives/2012/05/02/does-texting-hinder-social-skills/

Written by Lisa Drake

Maintaining Sensory Input Throughout Old Age May Be Beneficial to Brain

Is someone close to you aging rapidly and seeming less mentally sharp?   Researchers at Columbia University have recently compiled evidence that late life changes in sensory experience (such as a decrease in frequency or intensity of sensory input) may have a direct effect on the brains of aging loved ones.  These findings are based on a recent study in which researchers severed the whiskers of rats (which are generally used to sense information about the surrounding environment) and studied changes in the neural connections in the brains.  Compared to rats in control groups, rats with severed whiskers exhibited decay in axon connections (the fibers in the brain necessary for passing along electrical signals from one neuron to the next.  These effects were generally more evident in rats that were considered relatively old, and were evident throughout the lifespan.  Findings like this indicate that a significant and healthy amount of sensory input for the elderly may prevent negative changes in brain performance.  For a dramatic example of the positive effects of sensory input in the elderly, take a look at this video highlighting the positive effects of listening to music on people of advanced age:

For more info on the study outlined above, check out a detailed article on Science Daily at http://www.sciencedaily.com/releases/2012/05/120524123209.htm

Thursday, February 9, 2012

Demi Moore in Rehab for Anorexia

Star Demi Moore was recently admitted to Utah's Cirque Lodge Rehab Center to be treated for anorexia and addiction to prescription pills. Moore reportedly weighs under 100 pounds and doctors are not only watching her closely to control that her weight does not plummet, but also to ensure that she does not see her own weight. This is a common practice used at Cirque Lodge for patients dealing with eating disorders. 
Anorexia is a serious emotional disorder characterized by an obsessive desire to lose weight by starving oneself. It takes a toll on the human body and  leads to many other symptoms, both psychological and biological, including: depression, social withdrawal, fatigue, food obsession, heart and gastrointestinal complications, kidney function, flaky skin, brittle nails, and tooth loss. It is most prevalent in adolescent females, but can develop in someone of any age or gender. The disorder may be biologically based or may develop from environmental and social factors, such as a sense of lack of control, bullying, or a desire for attention. If you or someone you know has these symptoms or is suffering from an eating disorder, call a counselor as soon as possible and get help. It could make a huge difference.